This project is developed in the context of a national collaboration and aims to get better insights about how Heme-oxygenase-1 (HO-1) modulation in the tumor microenvironment impacts on prostate cancer progression. In fact, inflammation is recognized as a risk factor for cancer and several pro-inflammatory bio-molecules have a major impact on tumor cells themselves but also on the associate stroma. In fact, in response to oxidative injury and to counter the adverse effects of inflammation a fine control program of gene expression in order to restore cellular homeostasis is triggered. In this context, the enzyme heme oxygenase (HO-1) plays a major role. This project evaluates some original ideas about how the induction of this enzyme impacts on tumor angiogenesis and tumor-specific immune activation. These ideas have an important translation potential since concepts under evaluation may highly impact in tumor progression.

Investigadores Intervinientes (2)

Diego José Laderach

Investigador Adjunto

Daniel Georges Compagno

Investigador Independiente